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PONDR
Text Box: Predictor of Naturally Disordered Regions Disordered regions (DRs) are entire proteins or regions of proteins which lack a fixed tertiary structure, essentially being partially or fully unfolded. Such disordered regions have been shown to be involved in a variety of functions, including DNA recognition, modulation of specificity/affinity of protein binding, molecular threading, activation by cleavage, and control of protein lifetimes. Although these DRs lack a defined 3-D structure in their native states, they frequently undergo disorder-to-order transitions upon binding to their partners. As it is known that sequence determines structure, we assumed that sequence would determine lack of structure as well. To test this, we developed a series of neural network predictors (NNPs) that use amino acid sequence data to predict disorder in a given region. This collection of Predictors of Natural Disordered Regions is termed PONDR®. Please visit www.PONDR.com to obtain a free trial of our software! Text Box: Coming soon!

The end all solution to protein aggregation problems

The AquoProt™ technologies are the practical applications of utilizing the science of intrinsically disordered proteins (IDPs) to improve recombinant protein solubility.  The ultimate product mix will be an array of kits, clones and consumables, service contracts, and customized research contracts, all of which are based on IDP knowledge.